Podocyte number and density changes during early human life
نویسندگان
چکیده
منابع مشابه
Decreasing podocyte number during human kidney intrauterine development.
Nephron number at birth has relevant clinical importance with implications for long-term renal health. In recent years, the podocyte depletion hypothesis has emerged as an important concept in kidney pathology. This study was aimed at verifying whether human podocyte number changes significantly during intrauterine life. To this end, 62 subjects with gestational ages ranging from 20 to 41 wk we...
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متن کاملCALL FOR PAPERS Novel Mechanisms and Roles of Glomerular Podocytes Decreasing podocyte number during human kidney intrauterine development
A. Crobe,* M. Desogus,* A. Sanna, M. Fraschini, C. Gerosa, D. Fanni, V. Fanos, P. Van Eyken, and G. Faa Section of Pathology, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy; Department of Electrical and Electronics Engineering, University of Cagliari, Cagliari, Italy; NICU, Neonatal Pathology, Puericulture Institute and Neonatal Section, University of Cagliari, Cagliar...
متن کاملPodocyte number in the maturing rat kidney.
BACKGROUND/AIMS The podocyte is an important cell for maintaining the normal structure and function of the glomerulus. In recent years much attention has been given to the number of podocytes in glomeruli. During this time there has been a debate as to whether podocytes can divide after the capillary-loop stage of development. The aim of this study was to use an unbiased counting method to dete...
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Semaphorin3a (Sema3a), a chemorepellant guidance protein, plays crucial roles in neural, cardiac and peripheral vascular patterning. Sema3a is expressed in the developing nephron, mature podocytes and collecting tubules. Sema3a acts as a negative regulator of ureteric bud branching, but its function in glomerular development has not been examined. Here we tested the hypothesis that Sema3a regul...
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ژورنال
عنوان ژورنال: Pediatric Nephrology
سال: 2016
ISSN: 0931-041X,1432-198X
DOI: 10.1007/s00467-016-3564-5